Caveolin protein Essay Example | Topics and Well Written Essays - 250 words

Caveolin protein - Essay Example l of three (3) variants known as the caveloin-1 (CAV-1), caveolin-2 (CAV-2), and caveolin-3 (CAV-3) (Gussak and Antezelevitch 234; Williams and Lisanti). CAV-1 and CAV-2 can be found in most cells whereas CAV-3 can be found in muscle cells of the heart (Yuan, Garcia and Hales 275). Having a complete sequence status, the size of amino acid length of CAV-1 is 178 (UniProtKB). As a 21- to 24-kDa protein, CAV-1 is composed of 16 amino acids longer than CAV-2 and additional N-terminal 27 amino acids as compared to CAV-3 (Fielding 177). CAV-1 has two variants known as CAV-1ÃŽ ± (contains amino acid tyrosin 14) and CAV-1ÃŽ ² (does not contain the â€Å"first 31 amino acid present in CAV 1ÃŽ ±) (Mercier, Jasmin and Lisanti 18). Both CAV-1ÃŽ ± and 1ÃŽ ² can be found in the lungs whereas CAV-1ÃŽ ² can be found in the epithelial cells (Yuan, Garcia and Hales 275). With regards to internalization of the material, Garcia and Hales (275) explained that CAV-1 can be phosphorylated in â€Å"Rab4-labelled, Rab5-labelled or the early endosome antigen-1-labelled compartments which then subsequently move to the Rab11-associated compartment†. Tang, ZhaoLan, Philipp E. Scherer, Takashi Okamoto, et al. "Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle." Journal of Biological Chemistry 271.4 (1996):